Products – 5-Bromo-2-Chloro Benzoic Acid – Antidiabetic Intermediates

CAS: 21739-92-4

Chemical Name: 5‑bromo‑2‑chlorobenzoic acid

Molecular Weight: 235.46g/mol

Molecular Formula: C₇H₄BrClO₂

Physical Appearance: White to off‑white or light-yellow crystalline powder, lmore soluble in polar organic solvents like ethanol, methanol, or dichloromethane

5‑Bromo‑2‑Chlorobenzoic Acid (CAS No. 21739-92-4) is a crucial intermediate in the synthesis of SGLT2 inhibitors (gliflozin-class drugs) such as Dapagliflozin, Empagliflozin, Sotagliflozin, and Ertugliflozin, which are widely prescribed for the treatment of Type 2 Diabetes Mellitus (T2DM). Its halogenated benzoic acid structure serves as a vital building block in the construction of the aryl glucoside core found in these antidiabetic agents.

This intermediate is essential in facilitating key cross-coupling reactions (e.g., Suzuki or etherification) that introduce complex glucose or aryl-based substituents during the multi-step synthesis of SGLT2 inhibitors. Additionally, 5-Bromo-2-Chlorobenzoic Acid is utilized in medicinal chemistry for the development of heterocyclic scaffolds such as benzoxazoles and quinazolines, supporting research programs focused on anti-infective, anti-inflammatory, and anticancer therapies.

Our 5-Bromo-2-Chloro Benzoic Acid is manufactured under strict GMP conditions, ensuring the highest quality standards. The product undergoes rigorous quality control testing for identity, potency, purity, and safety before release.