N-[4-(Methylamino)benzoyl]-L-glutamic acid zinc salt
- Chemical Structure
- Chemical Details
- End Use
- Manufacturing & Quality Control
CAS: 66104-81-2
Chemical Name: N-[4-(Methylamino)benzoyl]-L-glutamic acid zinc salt
Molecular Weight: 343.64g/mol
Molecular Formula: C₁₃H₁₄N₂O₅Zn
Physical Appearance: Presumed white to off-white crystalline powder
N-[4-(Methylamino)benzoyl]-L-glutamic acid zinc salt (CAS No. 66104-81-2) is a key intermediate in the synthesis of Pemetrexed disodium, an antifolate chemotherapy drug used in the treatment of malignant pleural mesothelioma and non-small cell lung cancer (NSCLC). This zinc salt form offers enhanced stability during storage and handling, facilitating its conversion into the active pharmaceutical ingredient.
In the manufacturing process of pemetrexed, this intermediate forms part of the core folate analog structure, which is essential for inhibiting key folate-dependent enzymes involved in DNA and RNA synthesis in rapidly dividing cancer cells. Its role is critical in ensuring high-purity API production and consistent therapeutic efficacy in oncology treatments.
Our N-[4-(Methylamino)benzoyl]-L-glutamic acid zinc salt is manufactured under strict GMP conditions, ensuring the highest quality standards. The product undergoes rigorous quality control testing for identity, potency, purity, and safety before release.